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1

Oligonucleotide N3′→P5′ Phosphoramidates and Thio-Phoshoramidates as Potential Therapeutic Agents

Sergei M. Gryaznov

Journal:

Chemistry & Biodiversity

Year:

2010

Language:

english

File:

PDF, 8.85 MB

english, 2010

2

Synthesis of oligonucleotides via monomers with unprotected bases

Gryaznov, Sergei M., Letsinger, Robert L.

Journal:

Journal of the American Chemical Society

Year:

1991

Language:

english

File:

PDF, 277 KB

english, 1991

3

Oligonucleotide N3′→P5′ phosphoramidates as potential therapeutic agents

Sergei M Gryaznov

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1999

Language:

english

File:

PDF, 220 KB

english, 1999

4

A phosphoramidate substrate analog is a competitive inhibitor of the Tetrahymena group I ribozyme

Raven L Hanna, Sergei M Gryaznov, Jennifer A Doudna

Journal:

Chemistry & Biology

Year:

2000

Language:

english

File:

PDF, 521 KB

english, 2000

5

Telomerase targeted oligonucleotide thio-phosphoramidates in T24-luc bladder cancer cells

Z. Gunnur Dikmen, Woodring E. Wright, Jerry W. Shay, Sergei M. Gryaznov

Journal:

Journal of Cellular Biochemistry

Year:

2008

Language:

english

File:

PDF, 253 KB

english, 2008

6

In vitro Suicide Inhibition of Self-Splicing of a Group I Intron from Pneumocystis carinii by an N3′→ P5′Phosphoramidate Hexanucleotide

Stephen M. Testa, Sergei M. Gryaznov and Douglas H. Turner

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.58 MB

english, 1999

7

Structural RNA Mimetics: N3‘ → P5‘ Phosphoramidate DNA Analogs of HIV-1 RRE and TAR RNA Form A-Type Helices That Bind Specifically to Rev and Tat-Related Peptides †

Rigl, C. Ted, Lloyd, David H., Tsou, Dean S., Gryaznov, Sergei M., Wilson, W. David

Journal:

Year:

1997

Language:

english

File:

PDF, 358 KB

english, 1997

8

Antisense Binding Enhanced by Tertiary Interactions: Binding of Phosphorothioate and N3‘→P5‘ Phosphoramidate Hexanucleotides to the Catalytic Core of a Group I Ribozyme from the Mammalian Pathogen Pneumocystis c arinii †

Testa, Stephen M., Gryaznov, Sergei M., Turner, Douglas H.

Journal:

Year:

1998

Language:

english

File:

PDF, 138 KB

english, 1998

9

Novel Short Oligonucleotide Conjugates as Inhibitors of Human Telomerase

Pongracz, Krisztina, Li, Shihong, Herbert, Brittney-Shea, Pruzan, Ronald, Wunder, Ellen, Chin, Allison, Piatyszek, Mieczyslaw, Shay, Jerry, Gryaznov, Sergei M.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2003

Language:

english

File:

PDF, 181 KB

english, 2003

10

Antibacterial silver core spherical nucleic acids

Rische, Clayton H., Goel, Aakriti, Radovic-Moreno, Aleksandar F., Gryaznov, Sergei M.

Journal:

Materials Today Communications

Year:

2016

Language:

english

File:

PDF, 2.23 MB

english, 2016

11

A new approach to the synthesis of oligodeoxyribonucleotides with alkylamino groups linked to internucleotide phosphate groups

Sergei M. Gryaznov, Victor K. Potapov

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 237 KB

english, 1991

12

Antisense PNA tridecamers targeted to the coding region of ha-ras mRNA arrest polypeptide chain elongation

Nathalie Dias, Sonia Dheur, Peter E Nielsen, Sergei Gryaznov, Arthur Van Aerschot, Piet Herdewijn, Claude Hélène, Tula E Saison-Behmoaras

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 587 KB

english, 1999

13

Interaction of Human Telomerase with Its Primer Substrate

Wallweber, Gerald, Gryaznov, Sergei, Pongracz, Krisztina, Pruzan, Ronald

Journal:

Year:

2003

Language:

english

File:

PDF, 255 KB

english, 2003

14

The detection of oligonucleotide N3′ → P5′ phosphoramidate/RNA duplexes with capillary gel electrophoresis

Lawrence Dedionisio, Annette M. Raible, Sergei M. Gryaznov

Journal:

ELECTROPHORESIS

Year:

1998

Language:

english

File:

PDF, 453 KB

english, 1998

15

Inhibition of IL-6 in Mice by Anti-NF-κB Oligodeoxyribonucleotide N3′ → P5′ Phosphoramidates

Ling Wang, Sergei Gryaznov, Michael Nerenberg

Journal:

Year:

1999

Language:

english

File:

PDF, 414 KB

english, 1999

16

SPIE Proceedings [SPIE Twelfth International Symposium on Gas Flow and Chemical Lasers and High-Power Laser Conference - St. Petersburg, Russia (Monday 31 August 1998)] XII International Symposium on Gas Flow and Chemical Lasers and High-Power Laser Conference - Far-field distribution of pulse-repetitive CO2-laser radiation after propagation along strongly turbulent horizontal and slope atmospheric beamlet

Belousova, Inna M., Gorshkov, Alexander, Grigor'ev, Vladimir A., Gryaznov, N. A., Danilov, Oleg B., Kalitievsky, N. A., Knaak, S., Leonov, Sergei N., Semenov, Victor E., Vysotina, Nina V., Boreisho, A

Year:

1998

Language:

english

File:

PDF, 366 KB

english, 1998

17

Oligonucleotide Conjugate GRN163L Targeting Human Telomerase as Potential Anticancer and Antimetastatic Agent

Gryaznov, Sergei M., Jackson, Shalmica, Dikmen, Gunnur, Harley, Calvin, Herbert, Brittney-Shea, Wright, Woodring E., Shay, Jerry W.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2007

Language:

english

File:

PDF, 332 KB

english, 2007

18

Novel method for the synthesis of dinucleoside-( N3 ′ → P5 ′)-phosphoramidothioates

Kulik, Katarzyna, Kaczmarek, Renata, Baraniak, Janina, Ślepokura, Katarzyna, Gryaznov, Sergei

Journal:

Tetrahedron Letters

Year:

2017

Language:

english

File:

PDF, 626 KB

english, 2017

19

Oligonucleotide N3′→P5′ phosphoramidates as efficient telomerase inhibitors

Shea-Herbert, Brittney, Pongracz, Krisztina, Shay, Jerry W, Gryaznov, Sergei M

Journal:

Year:

2002

Language:

english

File:

PDF, 168 KB

english, 2002

20

Lipid modification of GRN163, an N3′ → P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition

Herbert, Brittney-Shea, Gellert, Ginelle C, Hochreiter, Amelia, Pongracz, Krisztina, Wright, Woodring E, Zielinska, Daria, Chin, Allison C, Harley, Calvin B, Shay, Jerry W, Gryaznov, Sergei M

Journal:

Year:

2005

Language:

english

File:

PDF, 284 KB

english, 2005

21

5 Efficient and high-fidelity copying of an RNA-like model prebiotic system

Zhang, Shenglong, Gryaznov, Sergei M., Szostak, Jack W.

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

2013

Language:

english

File:

PDF, 67 KB

english, 2013

22

Anchor for one step release of 3′-aminooligonucleotides from a solid support

Sergei M. Gryaznov, Robert L. Letsinger

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 250 KB

english, 1993

23

Sequencing of Phosphoramidate Oligonucleotides by Acid Hydrolysis and Mass Spectrometry

Pourshahian, Soheil, Gryaznov, Sergei

Journal:

Analytical Chemistry

Year:

2019

Language:

english

File:

PDF, 423 KB

english, 2019

24

arabino-Fluorooligonucleotide N3′→P5′ phosphoramidates: synthesis and properties

Ronald G Schultz, Sergei M Gryaznov

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 150 KB

english, 2000

25

Efficient Inhibition of Transcription Elongationin vitroby Oligonucleotide Phosphoramidates Targeted to Proviral HIV DNA

Carine Giovannangeli, Loı̈c Perrouault, Christophe Escudé, Sergei Gryaznov, Claude Hélène

Journal:

Journal of Molecular Biology

Year:

1996

Language:

english

File:

PDF, 421 KB

english, 1996

26

Contributions of Individual Nucleotides to Tertiary Binding of Substrate by a Pneumocystis carinii Group I Intron †

Disney, Matthew D., Gryaznov, Sergei M., Turner, Douglas H.

Journal:

Year:

2000

Language:

english

File:

PDF, 225 KB

english, 2000

27

Synthesis and Properties of the Oligonucleotide N3′ →P5′ Phosphoramidates

Gryaznov, Sergei M.

Journal:

Nucleosides and Nucleotides

Year:

1997

Language:

english

File:

PDF, 441 KB

english, 1997

28

A new affinity purification procedure for DNA-binding proteins using bromoacetyl agarose

Kang, Shin-Heh, Xu, Xiao, Heidenreich, Olaf, Gryaznov, Sergei, Nerenberg, Michael

Journal:

Nucleic Acids Research

Year:

1995

Language:

english

File:

PDF, 1.53 MB

english, 1995

29

A Remarkable Stabilization of Complexes Formed by 2,6-Diaminopurine Oligonucleotide N3′→P5′ Phosphoramidates

Matray, Tracy, Gamsey, Soya, Pongracz, Krisztina, Gryaznov, Sergei

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2000

Language:

english

File:

PDF, 872 KB

english, 2000

30

Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer

Ginelle C. Gellert, Z. Gunnur Dikmen, Woodring E. Wright, Sergei Gryaznov, Jerry W. Shay

Journal:

Breast Cancer Research and Treatment

Year:

2006

Language:

english

File:

PDF, 364 KB

english, 2006

31

DNA and RNA analogues – oligonucleotide phosphoramidates with bridging nitrogen

Banait, Narinder S, Gryaznov, Sergei M

Journal:

Expert Opinion on Therapeutic Patents

Year:

2002

Language:

english

File:

PDF, 247 KB

english, 2002

32

Enhancement of selectivity in recognition of nucleic acids via chemical autoligation

Gryaznov, Sergei M., Schultz, Ronald, Chaturvedi, Surendra K., Letsinger, Robert L.

Journal:

Nucleic Acids Research

Year:

1994

Language:

english

File:

PDF, 333 KB

english, 1994

33

Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma

Ferrandon, Sylvain, Malleval, Céline, El Hamdani, Badia, Battiston-Montagne, Priscillia, Bolbos, Radu, Langlois, Jean-Baptiste, Manas, Patrick, Gryaznov, Sergei M, Alphonse, Gersende, Honnorat, Jérôme

Journal:

Molecular Cancer

Year:

2015

Language:

english

File:

PDF, 818 KB

english, 2015

34

Oligodeoxyribonucleotide N3'.fwdarw.P5' Phosphoramidates: synthesis and Hybridization Properties

Gryaznov, Sergei, Chen, Jer-Kang

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 1.02 MB

english, 1994

35

Stable Triple Helices Formed by Oligonucleotide N3′→ P5′Phosphoramidates Inhibit Transcription Elongation

Christophe Escudé, Carine Giovannangeli, Jian-Sheng Sun, David H. Lloyd, Jer-Kang Chen, Sergei M. Gryaznov, Thérèse Garestier and Claude Hélène

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 984 KB

english, 1996

36

Electric-discharge VUV laser pumped by a solid-state generator

Vartapetov, Sergei K, Gryaznov, O V, Malashin, M V, Moshkunov, S I, Nebogatkin, S V, Khasaya, R R, Khomich, V Yu, Yamshchikov, V A

Journal:

Quantum Electronics

Year:

2009

Language:

english

File:

PDF, 218 KB

english, 2009

37

Accessibility of Nuclear DNA to Triplex-Forming Oligonucleotides: The Integrated HIV-1 Provirus as a Target

Carine Giovannangeli, Silvia Diviacco, Valérie Labrousse, Sergei Gryaznov, Pierre Charneau and Claude Helene

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.30 MB

english, 1997

38

Modulation of oligonucleotide duplex and triplex stability via hydrophobic interactions

Gryaznov, Sergei M., Lloyd, David H.

Journal:

Nucleic Acids Research

Year:

1993

Language:

english

File:

PDF, 619 KB

english, 1993

39

Oligonucleotide N3' → P5' Phosphoramidates

Sergei M. Gryaznov, David H. Lloyd, Jer-Kang Chen, Ronald G. Schultz, Lawrence A. DeDionisio, Lynda Ratmeyer and W. David Wilson

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 832 KB

english, 1995

40

Analysis of a ribonuclease H digestion of N3′ → P5′ phosphoramidate-RNA duplexes by capillary gel electrophoresis

Lawrence DeDionisio, Sergei M. Gryaznov

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1995

Language:

english

File:

PDF, 587 KB

english, 1995

41

Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab

Erin M. Goldblatt, Priscilla A. Erickson, Erin R. Gentry, Sergei M. Gryaznov, Brittney-Shea Herbert

Journal:

Breast Cancer Research and Treatment

Year:

2009

Language:

english

File:

PDF, 677 KB

english, 2009

42

Novel Short Oligonucleotide Conjugates as Inhibitors of Human Telomerase

Krisztina Pongracz, Shihong Li, Brittney-Shea Herbert, Ronald Pruzan, Ellen Wunder, Allison Chin, Mieczyslaw Piatyszek, Jerry Shay, Sergei M. Gryaznov

Journal:

Year:

2004

File:

PDF, 54 KB

2004

43

Telomere Shortening Sensitizes Cancer Cells to Selected Cytotoxic Agents: In Vitro and In Vivo Studies and Putative Mechanisms

Uziel, Orit, Beery, Einat, Dronichev, Vladimir, Samocha, Katty, Gryaznov, Sergei, Weiss, Lola, Slavin, Shimon, Kushnir, Michal, Nordenberg, Yardena, Rabinowitz, Claudette, Rinkevich, Baruch, Zehavi, T

Journal:

Year:

2010

Language:

english

File:

PDF, 1.28 MB

english, 2010

44

A new approach to synthesis of Oligonucleotides with 3′ phosphoryl groups

Sergei M. Gryaznov, Robert L. Letsinger

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 153 KB

english, 1992

45

Construction of branched DNA (bDNA) molecules by chemical ligation

Nina Dolinnaya, Sergei Gryaznov, David Ahle, Chu-An Chang, Zoe A. Shabarova, Mickey S. Ureda, Thomas Horn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 834 KB

english, 1994

46

An oligonucleotide complementary to the SL-B1 domain in the 3′-end of the minus-strand RNA of the hepatitis C virus inhibits in vitro initiation of RNA synthesis by the viral polymerase

Sandrine Reigadas, Michel Ventura, Marie-Line Andreola, Justine Michel, Sergei Gryaznov, Laura Tarrago-Litvak, Simon Litvak, Thérèse Astier-Gin

Journal:

Year:

2003

Language:

english

File:

PDF, 628 KB

english, 2003

47

Telomerase antagonist imetelstat inhibits esophageal cancer cell growth and increases radiation-induced DNA breaks

Xuping Wu, Shirin Smavadati, Katarina Nordfjäll, Krister Karlsson, Fredrik Qvarnström, Martin Simonsson, Michael Bergqvist, Sergei Gryaznov, Simon Ekman, Ylva Paulsson-Karlsson

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2012

Language:

english

File:

PDF, 745 KB

english, 2012

48

A new approach to oligonucleotide N3′ → P5′ phosphoramidate building blocks

Daria Zielinska, Krisztina Pongracz, Sergei M. Gryaznov

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 113 KB

english, 2006

49

Charged oxygen interstitials in corundum: first principles simulations

Platonenko, Alexander, Gryaznov, Denis, Piskunov, Sergei, Zhukovskii, Yuri F., Kotomin, Eugene A.

Journal:

Physica status solidi

Year:

2016

Language:

english

File:

PDF, 608 KB

english, 2016

50

Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells

Jaime Gomez-Millan, Erin M. Goldblatt, Sergei M. Gryaznov, Marc S. Mendonca, Brittney-Shea Herbert

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2007

Language:

english

File:

PDF, 695 KB

english, 2007

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